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Similarly, Tripathi et al

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VDR bound to Lyn and blocked its interaction with FcRI and myeloid differentiation primary response gene 88 (MyD88), attenuating downstream phosphorylation of Syk, activation of p38, and NF-B in BMMC

Defective ZDHHC21 function protects renal function and structure during sepsis injury by attenuating the reduction of renal blood flow, renal perfusion, and renal oxygen saturation

Further functional validation experiments clarified the regulatory logic between these two molecules